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Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory Demyelinating Polyneuropathy

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Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immunological disorder. Although the precise pathoetiology of CIDP has not been clarified yet, it is believed that both B and T cells of immune system contribute in this disorder. Based on the importance of human leukocyte antigen (HLA) cluster in the regulation of immune responses, this family of proteins is putative determinants of risk of CIDP. We conducted the current investigation to appraise association between HLA alleles/genotypes/haplotypes and risk of CIDP in Iranian patients. HLA-DQB1*02 allele was significantly more prevalent among cases compared with controls (OR [95% CI] = 4.82 [2.06, 11.3], P value = 0.000215, adjusted P value = 0.0124). A*01—B*52—C*12—DRB1*15—DQB1*02 and A*23—B*35—C*04—DRB1*11—DQB1*03 haplotypes with frequency of 0.03 were the most frequent HLA haplotypes. These haplotypes were not detected among healthy controls. The present study introduces HLA-DQB1*02 allele as a risk allele for CIDP among Iranian patients and further supports the importance of HLA region in this immunological condition.

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Data Availability

The analyzed data sets generated during the study are available from the corresponding author on reasonable request.

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Funding

This study was financially supported by Grant from Medical School of Shahid Beheshti University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  2. Tehran Medical Genetics Laboratory, Tehran, Iran

    Mohammad Taghi Akbari

  3. Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK

    Henry Houlden

  4. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Mehrdokht Mazdeh

  5. Department of Electrical Engineering, Sharif University of Technology, Tehran, Iran

    Naghme Nazer

  6. Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Omidvar Rezaei & Arezou Sayad

  7. Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

Authors
  1. Soudeh Ghafouri-Fard
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  2. Mohammad Taghi Akbari
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  3. Henry Houlden
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  4. Mehrdokht Mazdeh
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  5. Naghme Nazer
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  6. Omidvar Rezaei
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  7. Mohammad Taheri
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  8. Arezou Sayad
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Contributions

MT and SGF wrote the manuscript and revised it. AS and MTA supervised the study and performed the experiment. NN analyzed the data. OR and MM were the clinical consultant and assessed patients for inclusion in the study. All authors approved the manuscript.

Corresponding authors

Correspondence to Mohammad Taheri or Arezou Sayad.

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Research Involving Human and Animal Participants

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Ethical Approval

The study protocol was approved by the ethical committee of Shahid Beheshti University of Medical Sciences. All methods were performed in accordance with the relevant guidelines and regulations.

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Informed consent forms were obtained from all study participants.

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Not applicable.

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The authors declare no competing interests.

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Cite this article

Ghafouri-Fard, S., Akbari, M.T., Houlden, H. et al. Distribution of HLA Alleles and Genotypes in Patients with Chronic Inflammatory Demyelinating Polyneuropathy. J Mol Neurosci 72, 574–584 (2022). https://doi.org/10.1007/s12031-021-01902-x

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  • DOI: https://doi.org/10.1007/s12031-021-01902-x

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